Effect of sleep restriction on insulin sensitivity and energy metabolism in postmenopausal women: A randomized crossover trial.

ABSTRACT:

Objective

The aim of this study was to investigate the effect of sleep restriction (SR) on insulin sensitivity and energy metabolism in postmenopausal women.

Methods

In a randomized crossover trial, 14 women underwent four nights of habitual sleep (HS, 100% normal sleep) and SR (60% of HS) while following a eucaloric diet. Outcomes included the following: (1) insulin sensitivity by hyperinsulinemic-euglycemic clamp, defined as the glucose infusion rate (GIR); (2) resting metabolism and substrate oxidation by indirect calorimetry; and (3) glucose, insulin, and C-peptide concentrations following a standard meal test.

Results

Nine postmenopausal women (mean [SD], age 59 [4] years, BMI 28.0  [2.6] kg/m² ) were analyzed. Accelerometer-determined total time in be

SUBMITTER: Singh P 

PROVIDER: S-EPMC10191900 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature