Faster lung function decline in people living with HIV despite adequate treatment: a longitudinal matched cohort study.

ABSTRACT:

Introduction

Chronic lung disease is common among people living with HIV (PLWH). We hypothesised that PLWH receiving antiretroviral therapy (ART) have faster lung function decline than matched controls.

Methods

We performed a prospective matched cohort study by including ART-treated PLWH from the Copenhagen Co-morbidity in HIV Infection Study (n=705) and the INSIGHT Strategic Timing of Antiretroviral Treatment Pulmonary Substudy (n=425) and frequency matched population controls from the Copenhagen General Population Study (n=2895) in a 1:3 ratio. Eligible participants were ≥25 years old and had two spirometry tests separated by at least 2 years of follow-up. Forced expiratory volume in 1 s (FEV₁) decline (mL/year) was compared between PLWH and controls using a lin

SUBMITTER: Thudium RF 

PROVIDER: S-EPMC10191974 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature