Methylation-Based Biological Age and Hypertension Prevalence and Incidence.

ABSTRACT:

Background

Hypertension is common in older individuals and is a major risk factor for cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of biological age that capture age-related physiological change, disease risk, and mortality. The relationships between hypertension and DNA methylation-based biological age metrics have yet to be carefully described.

Methods

Among 4419 women enrolled in the prospective Sister Study cohort, DNA methylation data generated from whole blood samples collected at baseline were used to calculate 3 biological age metrics (PhenoAgeAccel, GrimAgeAccel, DunedinPACE). Women were classified as hypertensive at baseline if they had high blood pressure (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90

SUBMITTER: Kresovich JK 

PROVIDER: S-EPMC10192055 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature