A Sequential Multiple Assignment Randomized Trial of Symptom Management After Chemotherapy.

ABSTRACT:

Context

Many cancer survivors experience a lingering symptom burden after chemotherapy.

Objectives

In this sequential multiple assignment randomized trial, we tested optimal sequencing of two evidence-based interventions for symptom management.

Methods

Survivors of solid tumors (N = 451) were interviewed at baseline and stratified as high or low need for symptom management based on comorbidity and depressive symptoms. High need survivors were randomized initially to the 12-week Symptom Management and Survivorship Handbook (SMSH, N = 282) or 12-week SMSH with eight weeks of Telephone Interpersonal Counseling (TIPC, N = 93) added during weeks one to eight. After four weeks of the SMSH alone, non-responders on depression were re-randomized to continue with SMSH alone (N 

SUBMITTER: Sikorskii A 

PROVIDER: S-EPMC10192117 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature