MSX1-expression during the different phases in healthy human endometrium.

ABSTRACT:

Purpose

The human endometrium consists of different layers (basalis and functionalis) and undergoes different phases throughout the menstrual cycle. In a former paper, our research group was able to describe MSX1 as a positive prognosticator in endometrial carcinomas. The aim of this study was to examine the MSX1 expression in healthy endometrial tissue throughout the different phases to gain more insight on the mechanics of MSX-regulation in the female reproductive system.

Materials and methods

In this retrospective study, we investigated a total of 17 normal endometrial tissues (six during proliferative phase and five during early and six during late secretory phase). We used immunohistochemical staining and an immunoreactive score (IRS) to evaluate MSX1 expression. We als

SUBMITTER: Eppich S 

PROVIDER: S-EPMC10192152 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature