Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence.

ABSTRACT: Nuclear decoupling and softening are the main cellular mechanisms to resist mechanical stress-induced nuclear/DNA damage, however, its molecular mechanisms remain much unknown. Our recent study of Hutchinson-Gilford progeria syndrome (HGPS) disease revealed the role of nuclear membrane protein Sun2 in mediating nuclear damages and cellular senescence in progeria cells. However, the potential role of Sun2 in mechanical stress-induced nuclear damage and its correlation with nuclear decoupling and softening is still not clear. By applying cyclic mechanical stretch to mesenchymal stromal cells (MSCs) of WT and Zmpset24^-/- mice (Z24^-/-, a model for HGPS), we observed much increased nuclear damage in Z24^-/- MSCs, which also featured elevated Sun2 expression, RhoA

SUBMITTER: Yue X 

PROVIDER: S-EPMC10192198 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature