Milk glycan metabolism by intestinal bifidobacteria: insights from comparative genomics.

ABSTRACT: Bifidobacteria are early colonizers of the human neonatal gut and provide multiple health benefits to the infant, including inhibiting the growth of enteropathogens and modulating the immune system. Certain Bifidobacterium species prevail in the gut of breastfed infants due to the ability of these microorganisms to selectively forage glycans present in human milk, specifically human milk oligosaccharides (HMOs) and N-linked glycans. Therefore, these carbohydrates serve as promising prebiotic dietary supplements to stimulate the growth of bifidobacteria in the guts of children suffering from impaired gut microbiota development. However, the rational formulation of milk glycan-based prebiotics requires a detailed understanding of how bifidobacteria metabolize these carbohydrate

SUBMITTER: Arzamasov AA 

PROVIDER: S-EPMC10192226 | biostudies-literature | 2022 Oct-Dec

REPOSITORIES: biostudies-literature