The interaction between physical frailty and prognostic impact of heart failure medication in elderly patients.

ABSTRACT:

Aims

Frailty is highly prevalent and associated with poor prognoses in elderly patients with heart failure (HF). However, the potential effects of physical frailty on the benefits of HF medications in elderly patients with HF are unclear. We aimed to determine the influence of physical frailty on the prognosis of HF medications in elderly patients with HF with reduced and mildly reduced ejection fraction (HFr/mrEF).

Methods and results

From the combined HF database of the FRAGILE-HF and Kitasato cohorts, hospitalized HF patients with a left ventricular ejection fraction < 50% and age ≥ 65 years were analysed. Patients treated with or without renin-angiotensin-aldosterone system inhibitors (RAASi) and beta-blockers at discharge were compared. Physical frailty was defined by t

SUBMITTER: Abe T 

PROVIDER: S-EPMC10192227 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature