The short and long-term characteristics and outcomes of patients with grade 1 myocardial uptake on cardiac scintigraphy.

ABSTRACT:

Aims

This study aimed to characterize the final diagnosis and prognosis of patients with grade 1 myocardial scintigraphy uptake, which is an unequivocal result for the diagnosis of transthyretin cardiac amyloidosis (ATTR-CA) requiring further invasive investigation with tissue biopsy.

Methods and results

We retrospectively compared the clinical and imaging parameters of patients suspected for ATTR-CA (based on clinical and echocardiographic parameters) with grade 1 vs. grades 2/3 technetium pyrophosphate uptake on cardiac scintigraphy. Prospectively, grade 1 patients underwent re-evaluation for ATTR-CA at long term. Of the 132 ATTR-CA suspected patients, 89 (67%) were diagnosed as grade 1 and 43 (33%) as grades 2/3 uptake. Grade 1 vs. grades 2/3 patients were younger and fem

SUBMITTER: Itzhaki Ben Zadok O 

PROVIDER: S-EPMC10192239 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature