Real-world safety of neurohormonal antagonist initiation among older adults following a heart failure hospitalization.

ABSTRACT:

Aims

To optimize guideline-directed medical therapy for heart failure, patients may require the initiation of multiple neurohormonal antagonists (NHAs) during and following hospitalization. The safety of this approach for older adults is not well established.

Methods and results

We conducted an observational cohort study of 207 223 Medicare beneficiaries discharged home following a hospitalization for heart failure with reduced ejection fraction (HFrEF) (2008-2015). We performed Cox proportional hazards regression to examine the association between the count of NHAs initiated within 90 days of hospital discharge (as a time-varying exposure) and all-cause mortality, all-cause rehospitalization, and fall-related adverse events over the 90 day period following hospitalization.

SUBMITTER: Goyal P 

PROVIDER: S-EPMC10192242 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature