Comparison of liver fibrosis scores for predicting mortality and morbidity in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Liver fibrosis scores (LFSs) are non-invasive and effective tools for estimating cardiovascular risks. To better understand the advantages and limitations of currently available LFSs, we determined to compare the predictive values of LFSs in heart failure with preserved ejection fraction (HFpEF) for primary composite outcome, atrial fibrillation (AF), and other clinical outcomes.

Methods and results

This was a secondary analysis of the TOPCAT trial, and 3212 HFpEF patients were enrolled. Five LFSs, namely, non-alcoholic fatty liver disease fibrosis score (NFS), fibrosis-4 score (FIB-4), BARD, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio, and Health Utilities Index (HUI) scores were adopted. Cox proportional hazard model and competing risk regres

SUBMITTER: Cao Y 

PROVIDER: S-EPMC10192244 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature