Fibrosis-4 index identifies worsening renal function associated with adverse outcomes in acute heart failure.

ABSTRACT:

Aims

Worsening renal function (WRF) often develops during heart failure (HF) treatment. However, prognostic implications of WRF in acute HF remain controversial, and risk stratification of WRF is challenging. Although the fibrosis-4 index (FIB-4) was initially established as a liver fibrosis marker, recent studies show that high FIB-4 is associated with venous congestion and poor prognosis in acute HF. This study aimed to evaluate whether FIB-4 could identify prognostically relevant and non-relevant WRF in patients with acute HF.

Methods and results

We retrospectively analysed data from a single-centre registry on acute HF at our university hospital between January 2015 and June 2021. This study included patients with acute HF aged ≥20 years who were immediately hospitalized

SUBMITTER: Tsuda K 

PROVIDER: S-EPMC10192251 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature