Utility of fractional excretion of urea nitrogen in heart failure patients with chronic kidney disease.

ABSTRACT:

Aims

Maintenance of euvolaemia with diuretics is critical in heart failure (HF) patients with chronic kidney disease (CKD); however, it is challenging because no reliable marker of volume status exists. Fractional excretion of urea nitrogen (FEUN) is a useful index of volume status in patients with renal failure. We aimed to examine whether FEUN is a surrogate marker of volume status for risk stratification in HF patients with CKD.

Methods and results

We examined 516 HF patients with CKD (defined as discharge estimated glomerular filtration rate < 60 mL/min/1.73 m² ) whose FEUN was measured at discharge (median age, 80 years; 58% male). The patients were divided into four groups according to quartile FEUN value at discharge: low-FEUN, FEUN ≤ 32.1; medium-FEUN, 32.

SUBMITTER: Watanabe Y 

PROVIDER: S-EPMC10192260 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature