Dose titration of sacubitril/valsartan for heart failure with reduced ejection fraction: a real-world study.

ABSTRACT:

Aims

The study aims to explore the real-world titration patterns of sacubitril/valsartan in a chronic heart failure (HF) follow-up management system and the effect on the recovery of ventricular remodelling and cardiac function in China.

Methods and results

This is a single-centre, observational study of 153 adult outpatients with HF and reduced ejection fraction who were managed in the chronic HF follow-up management system and prescribed with sacubitril/valsartan from August 2017 to August 2021 in China. All patients tried to titrated sacubitril/valsartan to the tolerant dose during follow-up. The primary outcome was the proportion of patients who reached and maintained the target dose of sacubitril/valsartan. The main secondary outcomes were the changes in left atrium dia

SUBMITTER: Wang C 

PROVIDER: S-EPMC10192287 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature