Association between MMP2 gene polymorphisms and dilated cardiomyopathy in a Chinese Han population.

ABSTRACT:

Aims

Dilated cardiomyopathy (DCM) belongs to the common types of cardiomyopathies. The pathogenesis remains unclear despite the fact that various genes have been found associated with DCM. MMP2 is a zinc-dependent and calcium-containing secreted endoproteinases, which could cleave a broad spectrum of substrates including extracellular matrix components and cytokines. It has proved to play an important role in the cardiovascular diseases. This study aimed to investigate the potential role of MMP2 gene polymorphisms in DCM susceptibility and prognosis in a Chinese Han population.

Methods and results

A total of 600 idiopathic DCM patients and 700 healthy controls were enrolled. Patients with contact information were followed up for a median period of 28 months. Three tagged sin

SUBMITTER: Li S 

PROVIDER: S-EPMC10192288 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature