CD301b⁺ macrophage: the new booster for activating bone regeneration in periodontitis treatment.

ABSTRACT: Periodontal bone regeneration is a major challenge in the treatment of periodontitis. Currently the main obstacle is the difficulty of restoring the regenerative vitality of periodontal osteoblast lineages suppressed by inflammation, via conventional treatment. CD301b⁺ macrophages were recently identified as a subpopulation that is characteristic of a regenerative environment, but their role in periodontal bone repair has not been reported. The current study indicates that CD301b⁺ macrophages may be a constituent component of periodontal bone repair, and that they are devoted to bone formation in the resolving phase of periodontitis. Transcriptome sequencing suggested that CD301b⁺ macrophages could positively regulate osteogenesis-related processes. In vitr

SUBMITTER: Wang C 

PROVIDER: S-EPMC10192316 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature