Extracellular succinate induces spatially organized biofilm formation in Clostridioides difficile.

ABSTRACT: Clostridioides difficile infection associated to gut microbiome dysbiosis is the leading cause for nosocomial diarrhea. The ability of C. difficile to form biofilms has been progressively linked to its pathogenesis as well as its persistence in the gut. Although C. difficile has been reported to form biofilms in an increasing number of conditions, little is known about how these biofilms are formed in the gut and what factors may trigger their formation. Here we report that succinate, a metabolite abundantly produced by the dysbiotic gut microbiota, induces in vitro biofilm formation of C. difficile strains. We characterized the morphology and spatial composition of succinate-induced biofilms, and compared to non-induced or deoxycholate (DCA) induced biof

SUBMITTER: Auria E 

PROVIDER: S-EPMC10192414 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature