[^99mTc]-labelled anti-Programmed Death-Ligand 1 single-domain antibody SPECT/CT: a novel imaging biomarker for myocardial PD-L1 expression.

ABSTRACT:

Background

Myocardial programmed death-ligand 1 (PD-L1) expression is implicated in immune checkpoint inhibitor (ICI)-associated myocarditis. Measurement of myocardial PD-L1 expression may have potential use as a mechanistic and predictive biomarker. The aim of this study was to determine non-invasive assessment of myocardial PD-L1 expression using [^99mTc]-labelled anti-PD-L1 single-domain antibody (NM-01) SPECT/CT.

Methods

Thoracic [^99mTc]NM-01 SPECT/CT was performed in lung cancer patients (n = 10) at baseline and 9-weeks following anti-programmed cell death protein 1 (PD-1) therapy. Baseline and 9-week left ventricular and right ventricular to blood pool ratios (LV_max:BP) and (RV_max:BP) were measured. LV_max was compar

SUBMITTER: Nazir MS 

PROVIDER: S-EPMC10192461 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature