Comprehensive analysis of ferroptosis-related genes for clinical and biological significance in hepatocellular carcinoma.

ABSTRACT:

Objective

This study aims to build a prognostic model of hepatocellular carcinoma (HCC) with ferroptosis-associated genes and explore their molecular function.

Methods

Gene expression data and clinical information were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases and the International Cancer Genome Consortium (ICGC). A ferroptosis-associated gene set was obtained from the FerrDb database to identify differentially expressed genes. Then, we performed pathway enrichment analysis and immune infiltration analysis. A combined model based on ferroptosis-associated genes for predicting the overall survival of HCC was built by univariate and multivariate Cox regression analyses. Quantitative real-time polymerase chain reaction, Western

SUBMITTER: Wu Q 

PROVIDER: S-EPMC10192498 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature