Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments.

ABSTRACT:

Background

Gestational age (GA) and associated level of gastrointestinal tract maturation are major factors driving the initial gut microbiota composition in preterm infants. Besides, compared to term infants, premature infants often receive antibiotics to treat infections and probiotics to restore optimal gut microbiota. How GA, antibiotics, and probiotics modulate the microbiota's core characteristics, gut resistome and mobilome, remains nascent.

Methods

We analysed metagenomic data from a longitudinal observational study in six Norwegian neonatal intensive care units to describe the bacterial microbiota of infants of varying GA and receiving different treatments. The cohort consisted of probiotic-supplemented and antibiotic-exposed extremely preterm infants (n = 29), anti

SUBMITTER: Bargheet A 

PROVIDER: S-EPMC10192547 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature