Distinct patterning responses of wing and leg neuromuscular systems to different preaxial polydactylies.

ABSTRACT: The tetrapod limb has long served as a paradigm to study vertebrate pattern formation and evolutionary diversification. The distal part of the limb, the so-called autopod, is of particular interest in this regard, given the numerous modifications in both its morphology and behavioral motor output. While the underlying alterations in skeletal form have received considerable attention, much less is known about the accompanying changes in the neuromuscular system. However, modifications in the skeleton need to be properly integrated with both muscle and nerve patterns, to result in a fully functional limb. This task is further complicated by the distinct embryonic origins of the three main tissue types involved-skeleton, muscles and nerves-and, accordingly, how they are patterned and connecte

SUBMITTER: Luxey M 

PROVIDER: S-EPMC10192688 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature