White matter microstructural metrics are sensitively associated with clinical staging in Alzheimer's disease.

ABSTRACT:

Introduction

White matter microstructure may be abnormal along the Alzheimer's disease (AD) continuum.

Methods

Diffusion magnetic resonance imaging (dMRI) data from the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 627), Baltimore Longitudinal Study of Aging (BLSA, n = 684), and Vanderbilt Memory & Aging Project (VMAP, n = 296) cohorts were free-water (FW) corrected and conventional, and FW-corrected microstructural metrics were quantified within 48 white matter tracts. Microstructural values were subsequently harmonized using the Longitudinal ComBat technique and inputted as independent variables to predict diagnosis (cognitively unimpaired [CU], mild cognitive impairment [MCI], AD). Models were adjusted for age, sex, race/ethnicity, edu

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10192723 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature