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Isolation of the isopropanol extract components of the leaves of Ailanthus glandulosa by a new method.

ABSTRACT: The leaves of Ailanthus glandulosa were extracted with the Soxhlet apparatus using isopropanol. A new method was used to separate and isolate eleven chemical compounds present in the leaves of bird's tongue. The separation was carried out by column chromatography using displacement solvents (petroleum ether, chloroform, dichloromethane, methanol) and four eluates were obtained. The four eluates were treated with a number of solvents, yielding thirty-four compounds. The chemical content of the mordants was determined using GC/MS technology. The samples tested contained six ester compounds, three aldehyde compounds, three ketone compounds, two alcoholic compounds, eight carboxylic acid compounds, five silicone compounds, five aromatic compounds and one phosphate compound. Eleven compounds were isolated, the most important of which are: 2-naphthoxyacetic acid, 2,6-bis (1,1-dimethylethyl)-4-ethylphenol, 2,5-tert-butylnitrobenzene, 5-hexyl-2-furaldehyde, 16-nitrobicyclo [10.4.0] hexadecan-1-ol-13-one, cyclooctasiloxan hexadecamethyl.

SUBMITTER: Saad SY

PROVIDER: S-EPMC10192775 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Isolation of the isopropanol extract components of the leaves of <i>Ailanthus glandulosa</i> by a new method.

Saad Sawsan Youseff SY

Heliyon 20230430 5

The leaves of <i>Ailanthus glandulosa</i> were extracted with the Soxhlet apparatus using isopropanol. A new method was used to separate and isolate eleven chemical compounds present in the leaves of bird's tongue. The separation was carried out by column chromatography using displacement solvents (petroleum ether, chloroform, dichloromethane, methanol) and four eluates were obtained. The four eluates were treated with a number of solvents, yielding thirty-four compounds. The chemical content of ...[more]

PMID: 37215867

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Project description:Aralia elata, a renowned medicinal plant with a rich history in traditional medicine, has gained attention for its potential therapeutic applications. However, the leaves of this plant have been largely overlooked and discarded due to limited knowledge of their biological activity and chemical composition. To bridge this gap, a comprehensive study was conducted to explore the therapeutic potential of the 70% ethanol extract derived from Aralia elata leaves (LAE) for the treatment of cardiovascular disease (CVD). Initially, the cytotoxic effects of LAE on human umbilical vein endothelial cells (HUVECs) were assessed, revealing no toxicity within concentrations up to 5 μg/mL. This suggests that LAE could serve as a safe raw material for the development of health supplements and drugs aimed at promoting cardiovascular well-being. Furthermore, the study found that LAE extract demonstrated anti-inflammatory properties in HUVECs by modulating the PI3K/Akt and MAPK signaling pathways. These findings are particularly significant as inflammation plays a crucial role in the progression of CVD. Moreover, LAE extract exhibited the ability to suppress the expression of adhesion molecules VCAM-1 and ICAM-1, which are pivotal in leukocyte migration to inflamed blood vessels observed in various pathological conditions. In conjunction with the investigation on therapeutic potential, the study also established an optimal HPLC-PDA-ESI-MS/MS method to identify and confirm the chemical constituents present in 24 samples collected from distinct regions in South Korea. Tentative identification revealed the presence of 14 saponins and nine phenolic compounds, while further analysis using PCA and PLS-DA allowed for the differentiation of samples based on their geographical origins. Notably, specific compounds such as chlorogenic acid, isochlorogenic acid A, and quercitrin emerged as marker compounds responsible for distinguishing samples from different regions. Overall, by unraveling its endothelial protective activity and identifying key chemical constituents, this research not only offers valuable insights for the development of novel treatments but also underscores the importance of utilizing and preserving natural resources efficiently.

Dataset Information

Isolation of the isopropanol extract components of the leaves of Ailanthus glandulosa by a new method.

Publications

Isolation of the isopropanol extract components of the leaves of <i>Ailanthus glandulosa</i> by a new method.

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