Causality of gut microbiome and hypertension: A bidirectional mendelian randomization study.

ABSTRACT:

Background & aims

The pathogenesis of hypertension involves a diverse range of genetic, environmental, hemodynamic, and more causative factors. Recent evidence points to an association between the gut microbiome and hypertension. Given that the microbiota is in part determined by host genetics, we used the two-sample Mendelian randomization (MR) analysis to address the bidirectional causal link between gut microbiota and hypertension.

Methods

We selected genetic variants (P < 1  ×  10^-5) for gut microbiota (n = 18,340) from the MiBioGen study. Genetic association estimates for hypertension were extracted from genome-wide association study (GWAS) summary statistics on 54,358 cases and 408,652 controls. Seven complementary MR methods were implemented,

SUBMITTER: Li Y 

PROVIDER: S-EPMC10192878 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature