Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress.

ABSTRACT: Mice systemically lacking dipeptidyl peptidase-4 (DPP4) have improved islet health, glucoregulation, and reduced obesity with high-fat diet (HFD) feeding compared to wild-type mice. Some, but not all, of this improvement can be linked to the loss of DPP4 in endothelial cells (ECs), pointing to the contribution of non-EC types. The importance of intra-islet signaling mediated by α to β cell communication is becoming increasingly clear; thus, our objective was to determine if β cell DPP4 regulates insulin secretion and glucose tolerance in HFD-fed mice by regulating the local concentrations of insulinotropic peptides. Using β cell double incretin receptor knockout mice, β cell- and pancreas-specific Dpp4^-/- mice, we reveal that β cell incretin receptors are necessary

SUBMITTER: Fadzeyeva E 

PROVIDER: S-EPMC10192926 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature