Development and validation of a collagen signature to predict the prognosis of patients with stage II/III colorectal cancer.

ABSTRACT: The tumor, nodes and metastasis (TNM) classification system provides useful but incomplete prognostic information and lacks the assessment of the tumor microenvironment (TME). Collagen, the main component of the TME extracellular matrix, plays a nonnegligible role in tumor invasion and metastasis. In this cohort study, we aimed to develop and validate a TME collagen signature (CS_TME) for prognostic prediction of stage II/III colorectal cancer (CRC) and to compare the prognostic values of "TNM stage + CS_TME" with that of TNM stage alone. Results indicated that the CS_TME was an independent prognostic risk factor for stage II/III CRC (hazard ratio: 2.939, 95% CI: 2.180-3.962, p < 0.0001), and the integration of the TNM stage and CS_TME had a better p

SUBMITTER: Dong S 

PROVIDER: S-EPMC10192940 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature