Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway.

ABSTRACT:

Objectives

Insulin's ability to counterbalance catecholamine-induced lipolysis defines insulin action in adipose tissue. Insulin suppresses lipolysis directly at the level of the adipocyte and indirectly through signaling in the brain. Here, we further characterized the role of brain insulin signaling in regulating lipolysis and defined the intracellular insulin signaling pathway required for brain insulin to suppress lipolysis.

Methods

We used hyperinsulinemic clamp studies coupled with tracer dilution techniques to assess insulin's ability to suppress lipolysis in two different mouse models with inducible insulin receptor depletion in all tissues (IR^ΔWB) or restricted to peripheral tissues excluding the brain (IR^ΔPER). To identify the underlying signa

SUBMITTER: Metz M 

PROVIDER: S-EPMC10193009 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature