Associations Between Vascular Risk Factor Levels and Cognitive Decline Among Stroke Survivors.

ABSTRACT:

Importance

Incident stroke is associated with accelerated cognitive decline. Whether poststroke vascular risk factor levels are associated with faster cognitive decline is uncertain.

Objective

To evaluate associations of poststroke systolic blood pressure (SBP), glucose, and low-density lipoprotein (LDL) cholesterol levels with cognitive decline.

Design, setting, and participants

Individual participant data meta-analysis of 4 US cohort studies (conducted 1971-2019). Linear mixed-effects models estimated changes in cognition after incident stroke. Median (IQR) follow-up was 4.7 (2.6-7.9) years. Analysis began August 2021 and was completed March 2023.

Exposures

Time-dependent cumulative mean poststroke SBP, glucose, and LDL cholesterol levels.

Main outcomes an

SUBMITTER: Levine DA 

PROVIDER: S-EPMC10193182 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature