Effectiveness of S-1-Based Chemoradiotherapy in Patients 70 Years and Older With Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial.

ABSTRACT:

Importance

Double-agent intravenous chemotherapy concurrent with radiotherapy is the standard of care for patients with inoperable esophageal cancer. However, patients tend to tolerate intravenous chemotherapy less well with age and comorbidities. It is essential to find a better treatment modality that improves survival outcomes without reducing the quality of life.

Objective

To evaluate the effectiveness of simultaneous integrated boost radiotherapy (SIB-RT) with concurrent and consolidated oral S-1 chemotherapy for patients aged 70 years and older with inoperable esophageal squamous cell carcinoma (ESCC).

Design, setting, and participants

This multicenter, phase III randomized clinical trial was conducted between March 2017 and April 2020 in 10 centers in China. Pa

SUBMITTER: Wang X 

PROVIDER: S-EPMC10193185 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature