Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease.

ABSTRACT:

Importance

An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking. Effective interventions should target risk factors in the causal pathway to dementia.

Objective

To comprehensively disentangle potentially causal aspects of modifiable risk factors for Alzheimer disease (AD) to inspire new drug targeting and improved prevention.

Design, setting, and participants

This genetic association study was conducted using 2-sample univariable and multivariable mendelian randomization. Independent genetic variants associated with modifiable risk factors were selected as instrumental variables from genomic consortia. Outcome data for AD were obtained from th

SUBMITTER: European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration 

PROVIDER: S-EPMC10193187 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature