Hydrogen inhalation attenuates lung contusion after blunt chest trauma in mice.

ABSTRACT:

Background

Lung contusion caused by blunt chest trauma evokes a severe inflammatory reaction in the pulmonary parenchyma that may be associated with acute respiratory distress syndrome. Although hydrogen gas has antioxidant and anti-inflammatory effects and is protective against multiple types of lung injury at safe concentrations, the effects of inhaled hydrogen gas on blunt lung injury have not been previously investigated. Therefore, using a mouse model, we tested the hypothesis that hydrogen inhalation after chest trauma would reduce pulmonary inflammation and acute lung injury associated with lung contusion.

Methods

Inbred male C57BL/6 mice were randomly divided into 3 groups: sham with air inhalation, lung contusion with air inhalation, and lung contusion with 1.3% hyd

SUBMITTER: Ageta K 

PROVIDER: S-EPMC10193194 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature