Association between statin exposure and short-term mortality in patients with high-grade acute-on-chronic liver failure.

ABSTRACT:

Background & aims

Acute-on-chronic liver failure (ACLF) carries a high short-term mortality for patients with cirrhosis. Prior literature suggests that statin exposure may reduce the likelihood of ACLF events. However, it is unclear if statin exposure is associated with ACLF-related mortality. This study sought to determine the association between statin use and short-term mortality among patients hospitalised with ACLF.

Methods

This was a retrospective cohort study of Veterans Health Administration (VHA) patients diagnosed with cirrhosis between 2008 and 2021 and hospitalised with high-grade (2 or 3) ACLF. Patients were stratified into those with and without continuous statin exposure for at least 90 days prior to hospitalisation. Multivariable logistic regression models we

SUBMITTER: Chapin S 

PROVIDER: S-EPMC10193237 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature