Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity.

ABSTRACT: Elderly individuals are highly susceptible to influenza virus (IAV) infection and respond poorly to influenza vaccines. Although the generally accepted correlate of protection following influenza vaccination is neutralizing antibody titers, cytotoxic T cell activity has been found to be a better correlate in the elderly. This suggests that vaccines designed to protect against influenza in the elderly should induce both humoral and cellular immunity. The co-induction of T cell immunity is additionally advantageous, as virus-specific T cells are frequently cross-reactive against different strains of IAV. Here, we tested the capacity of a synthetic TLR-4 adjuvant, SLA-SE (second-generation lipid adjuvant formulated in a squalene-based oil-in-water emulsion) to elicit T cell immunity to a reco

SUBMITTER: Cookenham T 

PROVIDER: S-EPMC10193286 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature