Limit-Defying μ-Total Analysis System: Achieving Part-Per-Quadrillion Sensitivity on a Hierarchical Optofluidic SERS Sensor.

ABSTRACT: Optofluidic sensors have accelerated the growth of smart sensor platforms with improved sensitivity, reliability, and innovation. In this article, we report the integration of a surface-enhanced Raman scattering (SERS) material consisting of silver nanoparticle-decorated diatomaceous earth (AgNPs-DE) with a flow-through microfluidic device, building up a hierarchical structured micro-total analysis system (μ-TAS) capable of achieving part-per-quadrillion (ppq)-level sensitivity. By the synergic integration of millimeter-scale microfluidic devices and porous laboratory filter paper with a micrometer-sized crosslinked cellulosic network that carries SERS-active AgNPs-DE, which possesses submicron to nanometer regimes of photonic crystals and plasmonic nanostructures, we achieved enhanced mas

SUBMITTER: Juneja S 

PROVIDER: S-EPMC10193394 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature