Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage.

ABSTRACT:

Objective

Neonatal intraventricular hemorrhage (IVH) leads to posthemorrhagic hydrocephalus (PHH), brain injury, and long-term disability. Current therapy for IVH is based on treating PHH but does not address the underlying brain injury. In order to develop pharmacological treatment for IVH, there must be a better understanding of the underlying pathology of this disease. This study was designed to determine the time course of the acute inflammation and oxidative stress that may underlie the progressive pathology of IVH. The authors sought to understand the temporal relationships among inflammation, oxidative stress, and white matter pathology in a rat model of IVH.

Methods

A rat model of IVH consisting of hemoglobin injection into the lateral ventricle was used. Tissue was

SUBMITTER: Goulding DS 

PROVIDER: S-EPMC10193502 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature