Symptom-specific differential motor network modulation by deep brain stimulation in Parkinson's disease.

ABSTRACT:

Objective

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established neurosurgical treatment for the motor symptoms of Parkinson's disease (PD). While often highly effective, DBS does not always yield optimal therapeutic outcomes, and stimulation-induced adverse effects, including paresthesia, muscle contractions, and nausea/lightheadedness, commonly occur and can limit the efficacy of stimulation. Currently, objective metrics do not exist for monitoring neural changes associated with stimulation-induced therapeutic and adverse effects.

Methods

In the present study, the authors combined intraoperative functional MRI (fMRI) with STN DBS in 20 patients with PD to test the hypothesis that stimulation-induced blood oxygen level-dependent signals contained pr

SUBMITTER: Gibson WS 

PROVIDER: S-EPMC10193504 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature