A systematic review of the clinicopathological features and prognostic outcomes of DICER1-mutant malignant brain neoplasms.

ABSTRACT:

Objective

DICER1-mutant malignant brain neoplasms are very rare tumors, and published data have relied on case reports or small case series. In this review, the authors aimed to systematically summarize the types and distribution patterns of DICER1 mutations, clinicopathological characteristics, and prognostic outcomes of these tumors.

Methods

The authors searched PubMed and Web of Science for relevant studies. They included studies if they provided individual patient data of primary malignant brain tumors carrying DICER1 mutations.

Results

The authors found 16 studies consisting of 9 embryonal tumors with multilayered rosettes (ETMRs), 30 pineoblastomas, 52 primary intracranial sarcomas, and 27 pituitary blastomas. Pineoblastoma, ETMR, and pituitary blastoma were mor

SUBMITTER: Vuong HG 

PROVIDER: S-EPMC10193506 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature