Demonstration of magnetization transfer and relaxation normalized pH-specific pulse-amide proton transfer imaging in an animal model of acute stroke.

ABSTRACT:

Purpose

pH-weighted amide proton transfer (APT) MRI is promising to serve as a new surrogate metabolic imaging biomarker for refined ischemic tissue demarcation. APT MRI with pulse-RF irradiation (pulse-APT) is an alternative to the routine continuous wave (CW-) APT MRI that overcomes the RF duty cycle limit. Our study aimed to generalize the recently developed pH-specific magnetization transfer and relaxation-normalized APT (MRAPT) analysis to pulse-APT MRI in acute stroke imaging.

Methods

Multiparametric MRI, including CW- and pulse-APT MRI scans, were performed following middle cerebral artery occlusion in rats. We calculated pH-sensitive MTR_asym and pH-specific MRAPT contrast between the ipsilateral diffusion lesion and contralateral normal area.

Results

SUBMITTER: Sun PZ 

PROVIDER: S-EPMC10193556 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature