The relationship between clinical phenotype and kallikrein-kinin bioregulation in different forms of arthritis.

ABSTRACT:

Objective

Patients with rheumatoid arthritis (RA) have shown increased levels of neutrophils generating kallikrein-kinin peptides in blood which are potent mediators of inflammation. This study investigated the association between the bioregulation of kinin-mediated inflammation with the clinical, quality of life, and imaging characteristics (e.g. ultrasonography) of different arthritides.

Methods

Patients with osteoarthritis (OA, n = 29), gout (n = 10) and RA (n = 8) were recruited and screened for clinical symptoms, quality of life, and ultrasonographical assessment of arthritis. Blood neutrophils were assessed for the expression of bradykinin receptors (B1R and B2R), kininogens and kallikreins by immunocytochemistry with visualization by bright field microscopy. Levels of

SUBMITTER: Tan DBA 

PROVIDER: S-EPMC10193675 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature