Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the "TRPV1-NFATc1-ATF3" pathway and tumor microenvironment engineering.

ABSTRACT:

Background

Conventional dissolving microneedles (DMNs) face significant challenges in anti-melanoma therapy due to the lack of active thrust to achieve efficient transdermal drug delivery and intra-tumoral penetration.

Methods

In this study, the effervescent cannabidiol solid dispersion-doped dissolving microneedles (Ef/CBD-SD@DMNs) composed of the combined effervescent components (CaCO₃ & NaHCO₃) and CBD-based solid dispersion (CBD-SD) were facilely fabricated by the "one-step micro-molding" method for boosted transdermal and tumoral delivery of cannabidiol (CBD).

Results

Upon pressing into the skin, Ef/CBD-SD@DMNs rapidly produce CO₂ bubbles through proton elimination, significantly enhancing the skin permeation and tumoral penetrati

SUBMITTER: Shi J 

PROVIDER: S-EPMC10193696 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature