Efficacy and safety of duloxetine in chronic musculoskeletal pain: a systematic review and meta-analysis.

ABSTRACT:

Background

Chronic musculoskeletal pain (CMP) is a complex condition that is mainly treated with analgesic drugs. However, antidepressant intervention is also an important factor in the treatment of CMP. Duloxetine is an effective treatment option for patients with CMP as its antidepressant effect. The purpose of this article is to evaluate the efficacy and safety of duloxetine in treating CMP.

Databases and data treatment

We searched PubMed, Web of Science, Embase, Cochrane Library from inception to May, 2022. Randomized controlled trials (RCTs) evaluating the efficacy and safety of duloxetine versus placebo in patients with CMP were included. We identified 13 articles and studied a population of 4201 participants in 4 countries.

Results

This meta-analysis showed tha

SUBMITTER: Ma X 

PROVIDER: S-EPMC10193733 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature