ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.

ABSTRACT: Activated Cdc42-associated kinase (ACK), a non-receptor tyrosine kinase, is an effector for the small GTPase Cdc42. ACK is emerging as an important component of the cancer landscape and thus, a promising target for the treatment of many malignancies. ACK is also being increasingly recognized as a potentially influential player in the regulation of protein homoeostasis. The delicate equilibrium between protein synthesis and protein degradation is crucial for healthy cell function and dysregulation of protein homoeostasis is a common occurrence in human disease. Here, we review the molecular mechanisms by which ACK regulates the stability of diverse cellular proteins (e.g. EGFR, p27, p53, p85 isoforms and RhoGDI-3), some of which rely on the kinase activity of ACK while others, interestingly

SUBMITTER: Hodder S 

PROVIDER: S-EPMC10193877 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature