Non-canonical helical transitions and conformational switching are associated with characteristic flexibility and disorder indices in TRP and Kv channels.

ABSTRACT: Structural evidence and much experimental data have demonstrated the presence of non-canonical helical substructures (π and 3₁₀) in regions of great functional relevance both in TRP as in Kv channels. Through an exhaustive compositional analysis of the sequences underlying these substructures, we find that each of them is associated with characteristic local flexibility profiles, which in turn are implicated in significant conformational rearrangements and interactions with specific ligands. We found that α-to-π helical transitions are associated with patterns of local rigidity whereas α-to-3₁₀ transitions are mainly leagued with high local flexibility profiles. We also study the relationship between flexibility and protein disorder in the transmembrane domain of thes

SUBMITTER: Garcia-Morales A 

PROVIDER: S-EPMC10193913 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature