The <i>Chlamydia trachomatis</i> type III-secreted effector protein CteG induces centrosome amplification through interactions with centrin-2.

ABSTRACT: The centrosome is the main microtubule organizing center of the cell and is crucial for mitotic spindle assembly, chromosome segregation, and cell division. Centrosome duplication is tightly controlled, yet several pathogens, most notably oncogenic viruses, perturb this process leading to increased centrosome numbers. Infection by the obligate intracellular bacterium Chlamydia trachomatis (C.t.) correlates with blocked cytokinesis, supernumerary centrosomes, and multipolar spindles; however, the mechanisms behind how C.t. induces these cellular abnormalities remain largely unknown. Here we show that the secreted effector protein, CteG, binds to centrin-2 (CETN2), a key structural component of centrosomes and regulator of centriole duplication. Our data indicate that bo

SUBMITTER: Steiert B 

PROVIDER: S-EPMC10193975 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature