A proprioceptive feedback circuit drives Caenorhabditis elegans locomotor adaptation through dopamine signaling.

ABSTRACT: An animal adapts its motor behavior to navigate the external environment. This adaptation depends on proprioception, which provides feedback on an animal's body postures. How proprioception mechanisms interact with motor circuits and contribute to locomotor adaptation remains unclear. Here, we describe and characterize proprioception-mediated homeostatic control of undulatory movement in the roundworm Caenorhabditis elegans. We found that the worm responds to optogenetically or mechanically induced decreases in midbody bending amplitude by increasing its anterior amplitude. Conversely, it responds to increased midbody amplitude by decreasing the anterior amplitude. Using genetics, microfluidic and optogenetic perturbation response analyses, and optical neurophysiology, we elucidated

SUBMITTER: Ji H 

PROVIDER: S-EPMC10193984 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature