Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes.

ABSTRACT: An emerging role for the circadian clock in autophagy and lysosome function has opened new avenues for exploration in the field of neurodegeneration. The daily rhythms of circadian clock proteins may coordinate gene expression programs involved not only in daily rhythms but in many cellular processes. In the brain, astrocytes are critical for sensing and responding to extracellular cues to support neurons. The core clock protein BMAL1 serves as the primary positive circadian transcriptional regulator and its depletion in astrocytes not only disrupts circadian function but also leads to a unique cell-autonomous activation phenotype. We report here that astrocyte-specific deletion of Bmal1 influences endolysosome function, autophagy, and protein degradation dynamics. In vitro, Bmal

SUBMITTER: McKee CA 

PROVIDER: S-EPMC10194014 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature