The change of non-alcoholic fatty liver disease is associated with risk of incident diabetes.

ABSTRACT:

Background & aims

The effect of change in non-alcoholic fatty liver disease (NAFLD) status on incident diabetes has not been well studied. We aimed to investigate the association of NAFLD development and remission with the risk of incident diabetes during a median of 3.5-year follow-up.

Methods

A total of 2690 participants without diabetes were recruited in 2011-2012 and assessed for incident diabetes in 2014. Abdominal ultrasonography was used to determine the change of NAFLD. 75 g oral glucose tolerance test (OGTT) was performed to determine diabetes. NAFLD severity was assessed using Gholam's model. The odds ratios (ORs) for incident diabetes were estimated by logistic regression models.

Results

NAFLD was developed in 580 (33.2%) participants and NAFLD remission oc

SUBMITTER: Chen C 

PROVIDER: S-EPMC10194027 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature