Chromosomal aberrations and prognostic analysis of secondary acute myeloid leukemia-a retrospective study.

ABSTRACT:

Background

Secondary acute myeloid leukemia (S-AML) patients generally have a poor prognosis, but the chromosomal aberrations of S-AML have been rarely reported. We aimed to explore the chromosomal aberrations and clinical significance in patients with S-AML.

Patients and methods

The clinical characteristics and karyotypes of 26 patients with S-AML were retrospectively analyzed. The overall survival (OS) was measured from the time of the patients' transition to AML (i.e., at S-AML diagnosis).

Results

The study included 26 S-AML patients (13 males and 13 females), with a median age of 63 years (range, 20-77 years). They transformed from various hematologic malignancies or solid tumors; most of them were secondary to myelodysplastic syndrome (MDS). About 62% of t

SUBMITTER: Song M 

PROVIDER: S-EPMC10194067 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature