Antibiotic use in infants within the first year of life is associated with the appearance of antibiotic-resistant genes in their feces.

ABSTRACT:

Background

Antibiotic resistance, an increasing challenge, is not only a national threat but also a global threat. Carriage of resistance genes is not limited to adults alone, various microbiota niches present in the body system of children have been found to harbor bacteria carrying resistant genes, especially, their gut microbiota. This study aims to identify selected antibiotic-resistant genes from the fecal samples of infants and the association of antibiotics use with the occurrence of resistant genes in the infant's gut.

Methods

A total number of 172 metagenomic DNA samples previously extracted from stool samples of 28 Nigerian babies longitudinally within their first year of life were screened for the presence of ESBL genes (blaSHV, blaTEM, and bla

SUBMITTER: Fadeyi TE 

PROVIDER: S-EPMC10194068 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature