No associations in preregistered study of youth depression and functional connectivity of fronto-parietal and default mode networks.

ABSTRACT: Adolescence is characterized by vulnerability to the onset of major depressive disorder (MDD). The goal of this preregistered study was to assess neural correlates of depression symptoms in young adolescents, both cross-sectionally and longitudinally. The default mode network (DMN) is believed to support internal attention towards self-referential thoughts, while the fronto-parietal network (FPN) is theorized to support cognitive control and regulation of attention. As MDD diagnosis has been associated with heightened connectivity within DMN regions and diminished connectivity within FPN regions relative to healthy controls, our study builds upon group-difference analyses by using dimensional measures of depression severity. Our preregistered hypotheses were that within-DMN functional conn

SUBMITTER: Qu Y 

PROVIDER: S-EPMC10194089 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature